Condensation of muscimol or thiomuscimol with aminopyridazines yields GABA-A antagonists

Condensation of muscimol or thiomuscimol with aminopyridazines yields GABA-A antagonists Synthesis and Biological Evaluation of 4-(Aminomethyl)-1-hydroxypyrazole Analogues of Muscimol as γ-Aminobutyric Acid_A Receptor Agonists A Novel Class of Potent 3-Isoxazolol GABA_AAntagonists:  Design, Synthesis, and Pharmacology Synthesis and pharmacological evaluation of cis-2,3,3a,4,5,6,7,7a-octahydro-3-oxoisoxazolo[5,4-c]pyridine: a structural analog of the GABA agonist THIP Synthesis and structure-activity relationships of a series of aminopyridazine derivatives of .gamma.-aminobutyric acid acting as selective GABA-A antagonists Phosphorus analogs of .gamma.-aminobutyric acid, a new class of anticonvulsants Use of bicuculline, a GABA antagonist, as a template for the development of a new class of ligands showing positive allosteric modulation of the GABAA receptor Potential Anxiolytic Agents. Part 4: Novel Orally-Active N5-Substituted Pyrido[1,2-a]benzimidazoles with High GABA-A Receptor Affinity Phosphinic Acid Analogs of GABA. 1. New Potent and Selective GABAB Agonists 4,5,6,7-Tetrahydroisothiazolo[5,4-c]pyridin-3-ol and related analogs of THIP. Synthesis and biological activity