Synthesis and biological evaluation of 2,5-dihydropyrazolo[4,3-c]quinolin-3-ones, a novel series of PDE 4 inhibitors with low emetic potential and antiasthmatic properties

Synthesis and biological evaluation of 2,5-dihydropyrazolo[4,3-c]quinolin-3-ones, a novel series of PDE 4 inhibitors with low emetic potential and antiasthmatic properties Identification of 2,3-disubstituted pyridines as potent, non-emetic PDE4 inhibitors Design, synthesis and in vitro PDE4 inhibition activity of certain quinazolinone derivatives for treatment of asthma Synthesis and biological activities of 1-pyridylisoquinoline and 1-pyridyldihydroisoquinoline derivatives as PDE4 inhibitors Improvement of therapeutic index of phosphodiesterase type IV inhibitors as anti-Asthmatics Syntheses and evaluation of pyrido[2,3-d]pyrimidine-2,4-diones as PDE 4 inhibitors Aryl sulfonamides as selective PDE4 inhibitors Phthalazine PDE4 inhibitors. Part 3: The synthesis and in vitro evaluation of derivatives with a hydrogen bond acceptor 7-Methoxyfuro[2,3-c]pyridine-4-carboxamides as PDE4 Inhibitors: A Potential Treatment for Asthma 8-Methoxyquinoline-5-carboxamides as PDE4 inhibitors: a potential treatment for asthma