8-Methoxyquinoline-5-carboxamides as PDE4 inhibitors: a potential treatment for asthma

Bioorganic & Medicinal Chemistry Letters
2002.0

Abstract

A series of bicyclic heteroaryl ring systems was considered as a replacement for the 3-cyclopentyloxy-4-methoxyphenyl moiety in rolipram resulting in the discovery of 8-methoxyquinoline-5-carboxamides as potent inhibitors of phosphodiesterase type 4 (PDE4).

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