Novel C-ring analogues of 20( S )-camptothecin. Part 3: synthesis and their in vitro cytotoxicity of A-, B- and C-ring analogues

Bioorganic & Medicinal Chemistry Letters
2000.0

Abstract

Several 5-substituted alkoxy 20(S)-camptothecin analogues having A- and B-ring substituents were prepared via semi-synthesis. Most of these compounds were found to exhibit potent anti-cancer activity based on their in vitro cytotoxicity data obtained against human tumor cell lines.

Knowledge Graph

Similar Paper

Novel C-ring analogues of 20( S )-camptothecin. Part 3: synthesis and their in vitro cytotoxicity of A-, B- and C-ring analogues
Bioorganic & Medicinal Chemistry Letters 2000.0
Synthesis and in vitro cytotoxicity of C(20)(RS)-camptothecin analogues modified at both B (or A) and E ring
Bioorganic & Medicinal Chemistry Letters 1998.0
Plant antitumor agents. 25. Total synthesis and antileukemic activity of ring A substituted camptothecin analogs. Structure-activity correlations
Journal of Medicinal Chemistry 1987.0
Novel hexacyclic camptothecin derivatives. Part 1: Synthesis and cytotoxicity of camptothecins with an A-ring fused 1,3-oxazine ring
Bioorganic & Medicinal Chemistry Letters 2008.0
Plant antitumor agents. 23. Synthesis and antileukemic activity of camptothecin analogs
Journal of Medicinal Chemistry 1986.0
Synthesis and in vitro cytotoxicity of (RS)-20-desethyl-20-substituted camptothecin analogues
Bioorganic & Medicinal Chemistry Letters 1996.0
Synthesis and antitumor activity of 7-substituted 20(RS)-camptothecin analogues
Bioorganic & Medicinal Chemistry Letters 1996.0
Synthesis and in vitro cytotoxicity of hexacyclic camptothecin analogues
Bioorganic & Medicinal Chemistry Letters 1999.0
Synthesis and Antitumor Activity of Ring A- and F-Modified Hexacyclic Camptothecin Analogues
Journal of Medicinal Chemistry 1998.0
Synthesis and Biological Evaluation of Novel A-Ring Modified Hexacyclic Camptothecin Analogues
Journal of Medicinal Chemistry 2001.0