Synthesis and in vitro cytotoxicity of (RS)-20-desethyl-20-substituted camptothecin analogues

Bioorganic & Medicinal Chemistry Letters
1996.0

Abstract

Sixteen (RS)-20-desethyl-20-substituted camptothecin analogues were designed and prepared by total synthesis. These analogues were evaluated for cytotoxic activity against five tumor cell lines. The cytotoxic activity of compound 14fwas shown to be comparable to that of camptothecin.

Knowledge Graph

Similar Paper