Design, synthesis, and structure–activity relationship studies of ATP analogues as DNA gyrase inhibitors

Bioorganic & Medicinal Chemistry Letters
2000.0

Abstract

We report herein the design and synthesis of ATP-analogues, namely 4-amino-pyrazolo[3,4-d]pyrimidines and 4-amino-pyrazolo[1,5-a][1,3,5]triazines, with DNA gyrase inhibitory activity. Among these series, some compounds exhibited promising antibacterial activity.

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