Inhibition of fucosyltransferase V by a GDP–Azasugar

Bioorganic & Medicinal Chemistry Letters
2001.0

Abstract

A GDP-azasugar conjugate was synthesized starting from an enzymatically obtained phosphorylated azasugar. It inhibits human fucosyltransferase V at micromolar concentrations, which is discussed in terms of transition state analogy.

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