Rational design of a new series of pronucleotide

Bioorganic & Medicinal Chemistry Letters
2001.0

Abstract

A new pronucleotide series is described involving a two-step degradation process mediated by, respectively, carboxylesterase and phosphoramidase. Taking AZT as nucleosidyl moiety, it is shown that most of the compounds inhibit HIV replication in TK(-) cell line, which proves 5'-AZTMP delivery.

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