Evolution of anti-HIV drug candidates. Part 3: diarylpyrimidine (DAPY) analogues

Bioorganic & Medicinal Chemistry Letters
2001.0

Abstract

The synthesis and anti-HIV-1 activity of a series of diarylpyrimidines (DAPYs) are described. Several members of this novel class of non-nucleoside reverse transcriptase inhibitors (NNRTIs) are extremely potent against both wild-type and a panel of clinically significant single- and double-mutant strains of HIV-1.

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