Synthesis and acetylcholinesterase inhibition of 5-desamino huperzine A derivatives

Bioorganic & Medicinal Chemistry Letters
2001.0

Abstract

(E)- and (Z)-5-Desamino huperzine A derivatives have been synthesized using a new synthetic strategy towards the huperzine A skeleton. These derivatives showed AChE inhibition constants in the low micromolar range and thus display better activity than all previously synthesized C5 derivatives.

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