Synthesis of diaminobutane derivatives as potent Ca2+-Permeable AMPA receptor antagonists

Bioorganic & Medicinal Chemistry Letters
2001.0

Abstract

We synthesized diaminobutane derivatives as potent Ca(2+)-permeable AMPA receptor antagonists with non-hypotensive activity. Compound 10c showed selective Ca(2+)-permeable AMPA receptor antagonist activity and neuroprotective effects in transient global ischemia models in gerbils.

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