Synthesis of polyamine derivatives Having non-hypotensive Ca2+-permeable AMPA receptor antagonist activity

Bioorganic & Medicinal Chemistry Letters
2001.0

Abstract

In order to obtain non-hypotensive and Ca2+-permeable AMPA receptor antagonists, we have synthesized a series of 1,4-bis(4-piperidinylmethyl)diaminobutanes. Compounds 13b, c, f had desirable properties.

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