Amino acid phosphoramidate nucleosides: potential ADEPT/GDEPT substrates

Bioorganic & Medicinal Chemistry Letters
2001.0

Abstract

A series of aromatic, serum-stable, water soluble and nontoxic amino acid phosphoramidate monoesters of 5-fluoro-2'-deoxyuridine (FUdR) and 1-beta-arabinofuranosylcytosine (Ara-C) was shown to inhibit the cellular growth of the human leukemia cell line CCRF-CEM in the presence of human prostatic acid phosphatase (hPAP).

Knowledge Graph

Similar Paper

Amino acid phosphoramidate nucleosides: potential ADEPT/GDEPT substrates
Bioorganic & Medicinal Chemistry Letters 2001.0
Synthesis and Biological Activity of Aromatic Amino Acid Phosphoramidates of 5-Fluoro-2‘-deoxyuridine and 1-β-Arabinofuranosylcytosine:  Evidence of Phosphoramidase Activity
Journal of Medicinal Chemistry 1996.0
Phosphoramidates of 2′-β-d-arabinouridine (AraU) as phosphate prodrugs; design, synthesis, in vitro activity and metabolism
Bioorganic & Medicinal Chemistry 2010.0
Synthesis and Biological Activity of Novel 5-Fluoro-2‘-deoxyuridine Phosphoramidate Prodrugs
Journal of Medicinal Chemistry 2000.0
l-Aspartic and l-glutamic acid ester-based ProTides of anticancer nucleosides: Synthesis and antitumoral evaluation
Bioorganic & Medicinal Chemistry Letters 2016.0
Synthesis and anticancer activity of some 5-fluoro-2′-deoxyuridine phosphoramidates
Bioorganic & Medicinal Chemistry 2016.0
Lipophilic 5'-alkyl phosphate esters of 1-.beta.-D-arabinofuranosylcytosine and its N4-acyl and 2,2'-anhydro-3'-O-acyl derivatives as potential prodrugs
Journal of Medicinal Chemistry 1982.0
Synthesis, in Vitro Anti-Breast Cancer Activity, and Intracellular Decomposition of Amino Acid Methyl Ester and Alkyl Amide Phosphoramidate Monoesters of 3‘-Azido-3‘-deoxythymidine (AZT)
Journal of Medicinal Chemistry 2000.0
Phosphoramidate ProTides of the Anticancer Agent FUDR Successfully Deliver the Preformed Bioactive Monophosphate in Cells and Confer Advantage over the Parent Nucleoside
Journal of Medicinal Chemistry 2011.0
Synthesis and Biological Studies of Novel Nucleoside Phosphoramidate Prodrugs
Journal of Medicinal Chemistry 2001.0