Novel 5-Vinyl Pyrimidine Nucleosides with Potent anti-Hepatitis B Virus Activity

Bioorganic & Medicinal Chemistry Letters
2001.0

Abstract

Synthesis and antiviral activities of novel N-1 alkyl substituted pyrimidines, 1-[(2-hydroxyethoxy)methyl]-5-vinyluracil (5), 1-[(2-hydroxy-1-(hydroxymethyl)ethoxy)methyl]-5-vinyluracil (6), and 1-[4-hydroxy-3-(hydroxymethyl)-1-butyl]-5-vinyluracil (7) are reported. Compounds 6 and 7 were potent inhibitors of DHBV in cell culture, in contrast, all of the compounds described were devoid of activity against TK(+) HSV-1 and TK(-) HSV-1.

Knowledge Graph

Similar Paper

Novel 5-Vinyl Pyrimidine Nucleosides with Potent anti-Hepatitis B Virus Activity
Bioorganic & Medicinal Chemistry Letters 2001.0
Design and Synthesis of Novel 5-Substituted Acyclic Pyrimidine Nucleosides as Potent and Selective Inhibitors of Hepatitis B Virus
Journal of Medicinal Chemistry 2002.0
Synthesis and Antiviral Activity of Novel Acyclic Nucleoside Analogues of 5-(1-Azido-2-haloethyl)uracils
Journal of Medicinal Chemistry 2001.0
Antiviral activity of 2,3′-anhydro and related pyrimidine nucleosides against hepatitis B virus
Bioorganic & Medicinal Chemistry Letters 2010.0
Effect of Various Pyrimidines Possessing the 1-[(2-Hydroxy-1-(hydroxymethyl)ethoxy)methyl] Moiety, Able To Mimic Natural 2‘-Deoxyribose, on Wild-type and Mutant Hepatitis B Virus Replication
Journal of Medicinal Chemistry 2006.0
A new class of pyrimidine nucleosides: inhibitors of hepatitis B and C viruses
Bioorganic & Medicinal Chemistry Letters 2012.0
Discovery of imidazo[1,2-c]pyrimidin-5(6H)-one heterosubstituted nucleoside analogues with potent activity against human hepatitis B virus in vitro
Bioorganic & Medicinal Chemistry Letters 1997.0
Inhibition of Hepatitis B Virus (HBV) Replication by Pyrimidines Bearing an Acyclic Moiety:  Effect on Wild-Type and Mutant HBV
Journal of Medicinal Chemistry 2006.0
Synthesis and Anti-Herpes Virus Activity of 2‘-Deoxy-4‘-thiopyrimidine Nucleosides
Journal of Medicinal Chemistry 1996.0
Antiviral Activity of Various 1-(2′-Deoxy-β-<scp>d</scp>-lyxofuranosyl), 1-(2′-Fluoro-β-<scp>d</scp>-xylofuranosyl), 1-(3′-Fluoro-β-<scp>d</scp>-arabinofuranosyl), and 2′-Fluoro-2′,3′-didehydro-2′,3′-dideoxyribose Pyrimidine Nucleoside Analogues against Duck Hepatitis B Virus (DHBV) and Human Hepatitis B Virus (HBV) Replication
Journal of Medicinal Chemistry 2010.0