Stereoselective synthesis of 7α- and 7β-aminocholestanol as potent fungicidal drugs

Bioorganic & Medicinal Chemistry Letters
2001.0

Abstract

Potentially lymphotropic 7 alpha- and 7 beta-aminocholestanol were stereoselectively synthesized. In vitro bioassay studies have shown that these fungicidal lipidic derivatives possess strong antifungal activity against Candida spp resistant strains to amphotericin B, 5-fluorocytosine and azoles.

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