Differential modulation of the antifungal activity of amphotericin B by natural and ent-cholesterol

Bioorganic & Medicinal Chemistry Letters
2004.0

Abstract

The addition of exogenous ent-cholesterol suppressed the antifungal activity of the amphotericin B when added to cultures of Candida albicans, but to a lesser extent than natural cholesterol. There were no detectable differences between added 2a or 2b on the antifungal activities of jaspamide or bengazole A, two unrelated antifungal natural products.

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