Cytotoxic michael-type amine adducts of α-methylene lactones alantolactone and isoalantolactone

Bioorganic & Medicinal Chemistry Letters
2001.0

Abstract

Two series of cytotoxic (IC50, K562 cell line, 1-24 microM) alpha-aminomethyl substituted lactones 3 and 4 were prepared by stereoselective Michael-type addition of amines to alantolactone (1) and isoalantolactone (2). The lactones 1 and 2 and their amine adducts induce apoptosis and act as alkylating agents.

DOI： 10.1016/s0960-894x(00)00686-7

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