Synthesis and cytotoxic evaluation of halogenated α-exo-methylene-lactones

Bioorganic & Medicinal Chemistry
2020.0

Abstract

α-exo-Methylene-γ-butyrolactones and α-exo-methylene-δ-valerolactones constitute an important group of natural and bioactive products. A simple and general protocol of halolactonization of dienoic acids to obtain various α-exo-methylene-lactones in excellent yields is described. The resulting halogenated α-exo-methylene-lactones were found to exhibit potent cytotoxic activities.

DOI： 10.1016/j.bmc.2019.115281

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