4-Aryl/cycloalkyl-5-phenyloxazole derivatives as selective COX-2 inhibitors
Bioorganic & Medicinal Chemistry Letters
2002.0
Abstract
A series of 4-aryl/cycloalkyl-5-phenyloxazole derivatives was synthesized and evaluated for their ability to inhibit cyclooxygenase-2 (COX-2) and cyclooxygenase-1 (COX-1). These compounds were found to be potent and selective COX-2 inhibitors.