2,3-Diarylbenzopyran derivatives as a novel class of selective cyclooxygenase-2 inhibitors

Bioorganic & Medicinal Chemistry Letters
2003.0

Abstract

A new series of cyclooxygenase-2(COX-2) inhibitors with naturally occurring flavone as the main skeleton has been synthesized and their biological activities were evaluated for cyclooxygenase inhibitory activity. Rational structural modifications were applied to potent COX-2 inhibitors to obtain the desired pharmacokinetic profiles for improved oral anti-inflammatory activity.

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