Design and synthesis of novel inhibitors of gelatinase B

Bioorganic & Medicinal Chemistry Letters
2002.0

Abstract

A new method was developed to identify nonpeptidic metalloproteinase inhibitors with novel zinc binding groups. Application of this method to matrix metalloproteinase-9 resulted in the identification of aminomethyl benzimidazole analogue 7a with an IC(50)=13 microM.

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