Synthesis and structure–activity relationship of novel aminotetralin derivatives with high μ selective opioid affinity

Bioorganic & Medicinal Chemistry Letters
2002.0

Abstract

Several novel racemic aminotetralin derivatives have been prepared using a stereoselective aziridine ring opening reactions and were evaluated for their micro-opioid receptor binding affinity. Selectivity index towards other opioid receptors and antinociceptive activity in mice have been evaluated for the most potent derivatives.

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