Benzotrithiole 2-oxide: A new family of thiol-Activated DNA-Cleaving functionalities

Bioorganic & Medicinal Chemistry Letters
2002.0

Abstract

It was demonstrated in our studies that benzotrithiole 2-oxide was capable of causing efficient DNA cleavage in the presence of 2-mercaptoethanol or glutathione and exhibited potent cytotoxic properties against certain cancer cell lines.

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