Total Synthesis and Semi-Synthetic Approaches to Analogues of Antibacterial Natural Product Althiomycin

Bioorganic & Medicinal Chemistry Letters
2002.0

Abstract

Numerous analogues of the naturally occurring antibiotic althiomycin have been synthesised exploiting both total- and semi-synthetic methodologies. The antibacterial activity of these derivatives has been determined in whole cell assays and indicates the natural product exhibits a restricted SAR.

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