Amide derivatives of meclofenamic acid as selective cyclooxygenase-2 inhibitors

Bioorganic & Medicinal Chemistry Letters
2002.0

Abstract

This paper describes SAR studies involved in the transformation of the NSAID meclofenamic acid into potent and selective cyclooxygenase-2 (COX-2) inhibitors via neutralization of the carboxylate moiety in this nonselective COX inhibitor.

Knowledge Graph

Similar Paper

Amide derivatives of meclofenamic acid as selective cyclooxygenase-2 inhibitors
Bioorganic & Medicinal Chemistry Letters 2002.0
Synthesis and cyclooxygenase and 5-lipoxygenase inhibitory activity of some thiazolidene-4-one analogs of meclofenamic acid
Bioorganic & Medicinal Chemistry Letters 1992.0
Ester and Amide Derivatives of the Nonsteroidal Antiinflammatory Drug, Indomethacin, as Selective Cyclooxygenase-2 Inhibitors
Journal of Medicinal Chemistry 2000.0
Selective COX-2 inhibitors. Part 1: Synthesis and biological evaluation of phenylazobenzenesulfonamides
Bioorganic & Medicinal Chemistry Letters 2006.0
Selective COX-2 inhibitors. Part 2: Synthesis and biological evaluation of 4-benzylideneamino- and 4-phenyliminomethyl-benzenesulfonamides
Bioorganic & Medicinal Chemistry 2008.0
Synthesis and activity of sulfonamide-substituted 4,5-diaryl thiazoles as selective cyclooxygenase-2 inhibitors
Bioorganic & Medicinal Chemistry Letters 1999.0
Naphthalene derivatives: A new series of selective cyclooxygenase-2 inhibitors
Bioorganic & Medicinal Chemistry Letters 2001.0
4-Aryl/cycloalkyl-5-phenyloxazole derivatives as selective COX-2 inhibitors
Bioorganic & Medicinal Chemistry Letters 2002.0
Antiinflammatory agents. 3. Synthesis and pharmacological evaluation of 2-amino-3-benzoylphenylacetic acid and analogs
Journal of Medicinal Chemistry 1984.0
Design and synthesis of 1,3-diarylurea derivatives as selective cyclooxygenase (COX-2) inhibitors
Bioorganic & Medicinal Chemistry Letters 2008.0