Amide derivatives of meclofenamic acid as selective cyclooxygenase-2 inhibitors
Bioorganic & Medicinal Chemistry Letters
2002.0
Abstract
This paper describes SAR studies involved in the transformation of the NSAID meclofenamic acid into potent and selective cyclooxygenase-2 (COX-2) inhibitors via neutralization of the carboxylate moiety in this nonselective COX inhibitor.