Identification of potent and broad-Spectrum antibiotics from SAR studies of a synthetic vancomycin analogue

Bioorganic & Medicinal Chemistry Letters
2003.0

Abstract

Dimeric vancomycin analogues based on a lead compound identified from a library of synthetic analogues of vancomycin have up to 60-fold greater activity than vancomycin against vancomycin-resistant Enterococcus faecium (VRE, VanA phenotype). Simplified analogues have also been prepared and found to maintain activity against VRE and have broad-spectrum antibiotic activity.

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