Antibacterial activity of G6-quaternary ammonium derivatives of a lipophilic vancomycin analogue

Bioorganic & Medicinal Chemistry Letters
2002.0

Abstract

A series of G6-amino derivatives of a lipophilic vancomycin analogue was prepared. Antibacterial activity of the analogues was inversely proportional to the degree of substitution of the G6-nitrogen. The fully substituted (quaternary) analogues were essentially inactive against vanA phenotype VREF strains but retained substantial activity against other bacteria, a profile reminiscent of teicoplanin.

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