5-Aryl thiazolidine-2,4-diones as selective PPARγ agonists

Bioorganic & Medicinal Chemistry Letters
2003.0

Abstract

A series of 5-aryl thiazolidine-2,4-diones containing 4-phenoxyphenyl side chains was designed, synthesized, and evaluated for PPAR agonist activities. One such compound 28 exhibited comparable levels of glucose correction to rosiglitazone in the db/db mouse type 2 diabetes animal model.

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