5-Aryl thiazolidine-2,4-diones: discovery of PPAR dual α/γ agonists as antidiabetic agents

Bioorganic & Medicinal Chemistry Letters
2003.0

Abstract

A novel series of 5-aryl thiazolidine-2,4-diones based dual PPARalpha/gamma agonists was identified. A number of highly potent and orally bioavailable analogues were synthesized. Efficacy study results of some of these analogues in the db/db mice model of type 2 diabetes showed them superior to rosiglitazone in correcting hyperglycemia and hypertriglyceridemia.

Knowledge Graph

Similar Paper

5-Aryl thiazolidine-2,4-diones: discovery of PPAR dual α/γ agonists as antidiabetic agents
Bioorganic & Medicinal Chemistry Letters 2003.0
5-Aryl thiazolidine-2,4-diones as selective PPARγ agonists
Bioorganic & Medicinal Chemistry Letters 2003.0
Aryloxazolidinediones: identification of potent orally active PPAR dual α/γ agonists
Bioorganic & Medicinal Chemistry Letters 2003.0
Discovery of a Novel Series of Peroxisome Proliferator-Activated Receptor α/γ Dual Agonists for the Treatment of Type 2 Diabetes and Dyslipidemia
Journal of Medicinal Chemistry 2005.0
Design, synthesis, and biological evaluation of novel thiazolidinediones as PPARγ/FFAR1 dual agonists
European Journal of Medicinal Chemistry 2016.0
Pyridine-2-propanoic acids: Discovery of dual PPARα/γ agonists as antidiabetic agents
Bioorganic & Medicinal Chemistry Letters 2006.0
Pyridine-3-propanoic acids: Discovery of dual PPARα/γ agonists as antidiabetic agents
Bioorganic & Medicinal Chemistry Letters 2006.0
Design, synthesis, in silico molecular docking and biological evaluation of novel oxadiazole based thiazolidine-2,4-diones bis-heterocycles as PPAR-γ agonists
European Journal of Medicinal Chemistry 2014.0
Design and synthesis of novel and potent amide linked PPARγ/δ dual agonists
Bioorganic & Medicinal Chemistry Letters 2007.0
Revisiting glitazars: Thiophene substituted oxazole containing α-ethoxy phenylpropanoic acid derivatives as highly potent PPARα/γ dual agonists devoid of adverse effects in rodents
Bioorganic & Medicinal Chemistry Letters 2011.0