The role of 2′,3′-unsaturation on the antiviral activity of anti-HIV nucleosides against 3TC-resistant mutant (M184V)

The role of 2′,3′-unsaturation on the antiviral activity of anti-HIV nucleosides against 3TC-resistant mutant (M184V) Synthesis, Structure−Activity Relationships, and Mechanism of Drug Resistance of <scp>d</scp>- and <scp>l</scp>-β-3‘-Fluoro-2‘,3‘-unsaturated-4‘-thionucleosides as Anti-HIV Agents <scp>l</scp>-2‘,3‘-Didehydro-2‘,3‘-dideoxy-3‘-fluoronucleosides:  Synthesis, Anti-HIV Activity, Chemical and Enzymatic Stability, and Mechanism of Resistance Synthesis, Structure−Activity Relationships, and Drug Resistance of β-<scp>d</scp>-3‘-Fluoro-2‘,3‘-Unsaturated Nucleosides as Anti-HIV Agents Synthesis, Anti-HIV Activity, and Molecular Mechanism of Drug Resistance of <scp>l</scp>-2‘,3‘-Didehydro-2‘,3‘-dideoxy-2‘-fluoro-4‘-thionucleosides Structure−Activity Relationships of 2‘-Fluoro-2‘,3‘-unsaturated <scp>d</scp>-Nucleosides as Anti-HIV-1 Agents Synthesis, Antiviral Activity, and Mechanism of Drug Resistance of <scp>d</scp>- and <scp>l</scp>-2‘,3‘-Didehydro-2‘,3‘-dideoxy-2‘-fluorocarbocyclic Nucleosides Clicking 3′-Azidothymidine into Novel Potent Inhibitors of Human Immunodeficiency Virus Anti-HIV Activity of (−)-(2R,4R)-1- (2-Hydroxymethyl-1,3-dioxolan-4-yl)- thymine against Drug-Resistant HIV-1 Mutants and Studies of Its Molecular Mechanism Antiviral activity of novel 2′-fluoro-6′-methylene-carbocyclic adenosine against wild-type and drug-resistant hepatitis B virus mutants