Identification of a dual histamine H1/H3 receptor ligand based on the H1 antagonist chlorpheniramine

Bioorganic & Medicinal Chemistry Letters
2003.0

Abstract

Combining the first generation H(1) antihistamine chlorpheniramine (1) with H(3) ligands of the alkylamine type has led to the identification of compound 9d, a dual ligand of both the H(1) and H(3) receptors.

Knowledge Graph

Similar Paper

Identification of a dual histamine H1/H3 receptor ligand based on the H1 antagonist chlorpheniramine
Bioorganic & Medicinal Chemistry Letters 2003.0
Cholinesterase inhibitory activity of chlorophenoxy derivatives—Histamine H3 receptor ligands
Bioorganic & Medicinal Chemistry Letters 2016.0
Potential utility of histamine H3 receptor antagonist pharmacophore in antipsychotics
Bioorganic & Medicinal Chemistry Letters 2009.0
From histamine to imidazolylalkyl-sulfonamides: The design of a novel series of histamine H3-receptor antagonists
Bioorganic & Medicinal Chemistry Letters 1999.0
Synthesis and Pharmacological Identification of Neutral Histamine H<sub>1</sub>-Receptor Antagonists
Journal of Medicinal Chemistry 2003.0
Development of a New Class of Nonimidazole Histamine H<sub>3</sub> Receptor Ligands with Combined Inhibitory Histamine N-Methyltransferase Activity
Journal of Medicinal Chemistry 2002.0
Acidic elements in histamine H3 receptor antagonists
Bioorganic &amp; Medicinal Chemistry Letters 2010.0
Homologs of Histamine as Histamine H3 Receptor Antagonists: A New Potent and Selective H3 Antagonist, 4(5)-(5-Aminopentyl)-1H-imidazole
Journal of Medicinal Chemistry 1995.0
Piperidine variations in search for non-imidazole histamine H3 receptor ligands
Bioorganic &amp; Medicinal Chemistry 2008.0
Synthesis and in Vitro Pharmacology of a Series of New Chiral Histamine H<sub>3</sub>-Receptor Ligands:  2-(RandS)-Amino-3-(1H-imidazol-4(5)-yl)propyl Ether Derivatives
Journal of Medicinal Chemistry 1999.0