Design and synthesis of novel PPARα/γ/δ triple activators using a known PPARα/γ dual activator as structural template

Bioorganic & Medicinal Chemistry Letters
2003.0

Abstract

Using a known dual PPARalpha/gamma activator (5) as a structural template, SAR evaluations led to the identification of triple PPARalpha/gamma/delta activators (18-20) with equal potency and efficacy on all three receptors. These compounds could become useful tools for studying the combined biological effects of PPARalpha/gamma/delta activation.

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