Design, synthesis, and evaluation of 2-alkoxydihydrocinnamates as PPAR agonists

Bioorganic & Medicinal Chemistry Letters
2006.0

Abstract

A series of 2-alkoxydihydrocinnamates were synthesized as PPARgamma and PPARalpha dual agonists. In vitro studies in cell model showed that these compounds were efficacious. Compound 1g was found to be a potent PPARalpha/gamma dual agonist and will be further evaluated for the treatment of type II diabetes.

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