Array synthesis of novel lipodepsipeptide

Bioorganic & Medicinal Chemistry Letters
2003.0

Abstract

Synthetic array technology was utilized to rapidly synthesize and analyze a diverse set of reductive alkylation analogues of daptomycin. Analysis of the array suggested the use of polar functionality such as sulfonamides or amide or polar spaces such as piperazine would beneficially affect activity.

Knowledge Graph

Similar Paper

Array synthesis of novel lipodepsipeptide
Bioorganic & Medicinal Chemistry Letters 2003.0
Synthesis and Structure–Activity Relationship Studies of N-Terminal Analogues of the Antimicrobial Peptide Tridecaptin A<sub>1</sub>
Journal of Medicinal Chemistry 2014.0
Synthesis and biological activity of N-Acylated ornithine analogues of daptomycin
Bioorganic &amp; Medicinal Chemistry Letters 2003.0
Solid-phase synthesis and in vitro biological activity of a Thr4→Ser4 analog of daptomycin
Bioorganic &amp; Medicinal Chemistry Letters 2015.0
Structure-activity relationship of daptomycin analogues with substitution at (2S, 3R) 3-methyl glutamic acid position
Bioorganic &amp; Medicinal Chemistry Letters 2017.0
Structure–Activity Relationship Studies of a Series of Semisynthetic Lipopeptides Leading to the Discovery of Surotomycin, a Novel Cyclic Lipopeptide Being Developed for the Treatment of Clostridium difficile-Associated Diarrhea
Journal of Medicinal Chemistry 2015.0
Establishing the Structure–Activity Relationship of Daptomycin
ACS Medicinal Chemistry Letters 2020.0
Genetically Engineered Lipopeptide Antibiotics Related to A54145 and Daptomycin with Improved Properties
Antimicrobial Agents and Chemotherapy 2010.0
Structural Characterization of Daptomycin Analogues A21978C<sub>1-3</sub>(<scp>d</scp>-Asn<sub>11</sub>) Produced by a Recombinant <i>Streptomyces roseosporus</i> Strain
Journal of Natural Products 2007.0
Structural Characterization of Daptomycin Analogues A21978C<sub>1-3</sub>(<scp>d</scp>-Asn<sub>11</sub>) Produced by a Recombinant <i>Streptomyces roseosporus</i> Strain
Journal of Natural Products 2007.0