Heterocyclic ketones as inhibitors of histone deacetylase
Bioorganic & Medicinal Chemistry Letters
2003.0
Abstract
Several heterocyclic ketones were investigated as potential inhibitors of histone deacetylase. Nanomolar inhibitors such as 22 and 25 were obtained, the anti-proliferative activity of which were shown to be mediated by HDAC inhibition.