Heterocyclic ketones as inhibitors of histone deacetylase

Bioorganic & Medicinal Chemistry Letters
2003.0

Abstract

Several heterocyclic ketones were investigated as potential inhibitors of histone deacetylase. Nanomolar inhibitors such as 22 and 25 were obtained, the anti-proliferative activity of which were shown to be mediated by HDAC inhibition.

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