A novel series of histone deacetylase inhibitors incorporating hetero aromatic ring systems as connection units

Bioorganic & Medicinal Chemistry Letters
2003.0

Abstract

A series of structurally novel HDAC inhibitors, in which a hetero aromatic ring connects the spacer with the hydrophobic group, has been designed and synthesized. These new inhibitors are very potent in in vitro enzymatic assays and display antiproliferation activity against two human cancer cell lines.

DOI： 10.1016/j.bmcl.2003.07.012

Knowledge Graph

Similar Paper

A novel series of histone deacetylase inhibitors incorporating hetero aromatic ring systems as connection units
Bioorganic & Medicinal Chemistry Letters 2003.0
Design and synthesis of a novel class of histone deacetylase inhibitors
Bioorganic & Medicinal Chemistry Letters 2001.0
Novel amide derivatives as inhibitors of histone deacetylase: Design, synthesis and SAR
European Journal of Medicinal Chemistry 2009.0
Design, synthesis and activity evaluation of indole-based double – Branched HDAC1 inhibitors
Bioorganic & Medicinal Chemistry 2019.0
Design and synthesis of aryl ether and sulfone hydroxamic acids as potent histone deacetylase (HDAC) inhibitors
Bioorganic & Medicinal Chemistry Letters 2011.0
The design, synthesis and structure–activity relationships of novel isoindoline-based histone deacetylase inhibitors
Bioorganic & Medicinal Chemistry Letters 2011.0
Design, synthesis and preliminary bioactivity evaluations of substituted quinoline hydroxamic acid derivatives as novel histone deacetylase (HDAC) inhibitors
Bioorganic & Medicinal Chemistry 2015.0
Design and synthesis of novel pyrimidine hydroxamic acid inhibitors of histone deacetylases
Bioorganic & Medicinal Chemistry Letters 2010.0
Set-up of a new series of HDAC inhibitors: the 5,11-dihydrodibenzo[b,e]azepin-6-ones as privileged structures
Bioorganic & Medicinal Chemistry Letters 2012.0
Alkyl piperidine and piperazine hydroxamic acids as HDAC inhibitors
Bioorganic & Medicinal Chemistry Letters 2011.0