The synthesis and antibacterial activity of 1,3,4-Thiadiazole phenyl oxazolidinone analogues

Bioorganic & Medicinal Chemistry Letters
2003.0

Abstract

Replacement of the morpholine C-ring of linezolid 1 with a 1,3,4-thiadiazolyl ring leads to oxazolidinone analogues 5 having potent antibacterial activity against both gram-positive and gram-negative organisms. Conversion of the C5 acetamide group to a thioacetamide further increases the potency of these compounds.

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