Novel promising linezolid analogues: Rational design, synthesis and biological evaluation

European Journal of Medicinal Chemistry
2013.0

Abstract

A new series of 5-substituted oxazolidinones derived from linezolid, having urea and thiourea moieties at the C-5 side chain of the oxazolidinone ring, were prepared and their in vitro antibacterial activity was evaluated. The compound 10f demonstrated high antimicrobial activity, comparable to that of linezolid against Staphylococcus aureus.

Knowledge Graph

Similar Paper

Novel promising linezolid analogues: Rational design, synthesis and biological evaluation
European Journal of Medicinal Chemistry 2013.0
Synthesis and antibacterial activity of linezolid analogues
Bioorganic & Medicinal Chemistry Letters 2002.0
The synthesis and antibacterial activity of 1,3,4-Thiadiazole phenyl oxazolidinone analogues
Bioorganic & Medicinal Chemistry Letters 2003.0
Synthesis and in vitro/in vivo antibacterial activity of oxazolidinones having thiocarbamate at C-5 on the A-ring and an amide- or urea-substituted [1,2,5]triazepane or [1,2,5]oxadiazepane as the C-ring
European Journal of Medicinal Chemistry 2013.0
Synthesis, SAR, and antibacterial activity of novel oxazolidinone analogues possessing urea functionality
Bioorganic & Medicinal Chemistry Letters 2008.0
Synthesis and in vitro antibacterial activities of novel oxazolidinones☆
European Journal of Medicinal Chemistry 2008.0
Synthesis and antibacterial activity of dihydro-1,2-oxazine and 2-pyrazoline oxazolidinones: novel analogs of linezolid
Bioorganic & Medicinal Chemistry Letters 2005.0
Synthesis and biological evaluation of new N-linked 5-triazolylmethyl oxazolidinones
European Journal of Medicinal Chemistry 2008.0
New linezolid-like 1,2,4-oxadiazoles active against Gram-positive multiresistant pathogens
European Journal of Medicinal Chemistry 2013.0
Synthesis and in vitro antibacterial activity of novel methylamino piperidinyl oxazolidinones
Bioorganic & Medicinal Chemistry Letters 2007.0