Heterocyclic aminopyrrolidine derivatives as melatoninergic agents

Bioorganic & Medicinal Chemistry Letters
2003.0

Abstract

A series of chiral heterocyclic aminopyrrolidine derivatives was synthesized as novel melatoninergic ligands. Binding affinity assays were performed on cloned human MT(1) and MT(2) receptors, stably expressed in NIH3T3 cells. Compound 16 was identified as an orally bioavailable agonist at MT(1) and MT(2) melatonin receptors with low vasoconstrictive activity.

Knowledge Graph

Similar Paper

Heterocyclic aminopyrrolidine derivatives as melatoninergic agents
Bioorganic & Medicinal Chemistry Letters 2003.0
Synthesis and structure–activity relationship of novel benzoxazole derivatives as melatonin receptor agonists
Bioorganic & Medicinal Chemistry Letters 2004.0
Design and synthesis of 1-(2-alkanamidoethyl)-6-methoxy-7-azaindole derivatives as potent melatonin agonists
Bioorganic & Medicinal Chemistry Letters 2011.0
Design and synthesis of 4-arylpiperidinyl amide and N-arylpiperdin-3-yl-cyclopropane carboxamide derivatives as novel melatonin receptor ligands
Bioorganic & Medicinal Chemistry Letters 2011.0
N-{2-[2-(4-Phenylbutyl)benzofuran-4-yl]cyclopropylmethyl}acetamide: an orally bioavailable melatonin receptor agonist
Bioorganic & Medicinal Chemistry Letters 2004.0
(R)-2-(4-Phenylbutyl)dihydrobenzofuran derivatives as melatoninergic agents
Bioorganic & Medicinal Chemistry Letters 2005.0
Discovery of a Potent and Orally Bioavailable Melatonin Receptor Agonist
Journal of Medicinal Chemistry 2021.0
Design, synthesis, and pharmacological effects of structurally simple ligands for MT1 and MT2 melatonin receptors
Bioorganic & Medicinal Chemistry 2010.0
Synthesis and pharmacological evaluation of 1,2,3,4-tetrahydropyrazino[1,2-a]indole and 2-[(phenylmethylamino)methyl]-1H-indole analogues as novel melatoninergic ligands
Bioorganic & Medicinal Chemistry 2009.0
Design and synthesis of benzoxazole derivatives as novel melatoninergic ligands
Bioorganic & Medicinal Chemistry Letters 2004.0