Synthesis and structure–activity relationship of novel benzoxazole derivatives as melatonin receptor agonists

Bioorganic & Medicinal Chemistry Letters
2004.0

Abstract

A series of benzoxazole derivatives was synthesized and evaluated as melatoninergic ligands. The binding affinity of these compounds for human MT(1) and MT(2) receptors was determined using 2-[(125)I]-iodomelatonin as the radioligand. From this series of benzoxazole derivatives, compounds 14 and 17 were identified as melatonin receptor agonists.

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