Synthesis and antibacterial activity of O-substituted nocathiacin I derivatives

Bioorganic & Medicinal Chemistry Letters
2004.0

Abstract

The synthesis and antibacterial activity of a series of new nocathiacin I derivatives (1-12) containing polar water solubilizing groups is described. Most of these compounds exhibited potent antibacterial activity and have improved water solubility. In addition, compounds 5, 7-9 also exhibited potent in vivo activity.

Knowledge Graph

Similar Paper