Synthesis, in vitro, and in vivo antibacterial activity of nocathiacin I thiol-Michael adducts

Bioorganic & Medicinal Chemistry Letters
2005.0

Abstract

The synthesis and antibacterial activity of a series of nocathiacin I derivatives (4-20) containing polar water solubilizing groups is described. Thiol-Michael adducts containing acidic polar groups have reduced antibacterial activity whereas those with basic polar groups have retained very good antibacterial activity.

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