Synthesis and evaluation of novel bacterial rRNA-binding benzimidazoles by mass spectrometry

Bioorganic & Medicinal Chemistry Letters
2004.0

Abstract

A series of novel benzimidazoles were efficiently synthesized using both solution- and solid-phase chemistry. These compounds were found to bind to the bacterial 16S ribosomal RNA A-site with micromolar affinities using unique mass spectrometry-based assays.

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