Antimalarial activities of (+)-deoxoartemisitene and its novel C-11, 13 derivatives

Bioorganic & Medicinal Chemistry Letters
2004.0

Abstract

(+)-Deoxoartemisitene and its C-11, 13 derivatives were synthesized from artemisinic acid via a short and regiospecific process and several derivatives show 10-20 times more in vitro antimalarial activities against Plasmodium falciparum than artemisinin.

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