Synthesis and anticancer activity of novel amide derivatives of non-acetal deoxoartemisinin

Bioorganic & Medicinal Chemistry Letters
2009.0

Abstract

Novel amide derivatives of C-12 non-acetal deoxoartemisinin were synthesized. Some of the derivatives had potent in vitro anticancer activity against major human cancer cell lines. The deoxoartemisinin amide trimer had potent in vivo antiangiogenic activity, according to the mouse matrigel plug assay.

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