Pyridine-2-propanoic acids: Discovery of dual PPARα/γ agonists as antidiabetic agents

Bioorganic & Medicinal Chemistry Letters
2006.0

Abstract

A series of novel pyridine-2-propanoic acids was synthesized. A structure-activity relationship study of these compounds led to the identification of potent dual PPARalpha/gamma agonists with varied isoform selectivity. Based on the results of efficacy studies in diabetic (db/db) mice, and the desired pharmacokinetic parameters, compound (S)-13 was selected for further profiling.

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