Synthesis and pharmacological evaluation of cis-2,3,3a,4,5,6,7,7a-octahydro-3-oxoisoxazolo[5,4-c]pyridine: a structural analog of the GABA agonist THIP

Synthesis and pharmacological evaluation of cis-2,3,3a,4,5,6,7,7a-octahydro-3-oxoisoxazolo[5,4-c]pyridine: a structural analog of the GABA agonist THIP Condensation of muscimol or thiomuscimol with aminopyridazines yields GABA-A antagonists 4,5,6,7-Tetrahydroisothiazolo[5,4-c]pyridin-3-ol and related analogs of THIP. Synthesis and biological activity Partial GABAA Receptor Agonists. Synthesis and in Vitro Pharmacology of a Series of Nonannulated Analogs of 4,5,6,7-Tetrahydroisoxazolo[4,5-c]pyridin-3-ol Synthesis and Biological Evaluation of 4-(Aminomethyl)-1-hydroxypyrazole Analogues of Muscimol as γ-Aminobutyric Acid_A Receptor Agonists GABA agonists. Resolution, absolute stereochemistry and enantioselectivity of (S)-(+)- and (R)-(-)-dihydromuscimol A Novel Class of Potent 3-Isoxazolol GABA_AAntagonists:  Design, Synthesis, and Pharmacology Glycine antagonists. Synthesis, structure, and biological effects of some bicyclic 5-isoxazolol zwitterions Synthesis of GABA_AReceptor Agonists and Evaluation of their α-Subunit Selectivity and Orientation in the GABA Binding Site Hydroxy-1,2,5-oxadiazolyl Moiety as Bioisoster of the Carboxy Function. Synthesis, Ionization Constants, and Pharmacological Characterization of γ-Aminobutyric Acid (GABA) Related Compounds