Novel renin inhibitors containing analogs of statine retro-inverted at the C-termini. Specificity at the P2 histidine site

Novel renin inhibitors containing analogs of statine retro-inverted at the C-termini. Specificity at the P2 histidine site Orally potent human renin inhibitors derived from angiotensinogen transition state: design, synthesis, and mode of interaction Renin inhibitors. Syntheses of subnanomolar, competitive, transition-state analog inhibitors containing a novel analog of statine The P1 N-isopropyl motif bearing hydroxyethylene dipeptide isostere analogues of aliskiren are in vitro potent inhibitors of the human aspartyl protease renin Pepstatin analogs as novel renin inhibitors Design and synthesis of a potent and specific renin inhibitor with a prolonged duration of action in vivo Novel inhibitors of human renin. Cyclic peptides based on the tetrapeptide sequence Glu-D-Phe-Lys-D-Trp Design and synthesis of potent macrocyclic renin inhibitors Design, structure-activity, and molecular modeling studies of potent renin inhibitory peptides having N-terminal Nin-For-Trp (Ftr): angiotensinogen congeners modified by P1-P1' Phe-Phe, Sta, Leu.psi.[CH(OH)CH2]Val or Leu.psi.[CH2NH]Val substitutions Inhibition of cathepsin D by substrate analogs containing statine and by analogs of pepstatin