The P1 N-isopropyl motif bearing hydroxyethylene dipeptide isostere analogues of aliskiren are in vitro potent inhibitors of the human aspartyl protease renin

The P1 N-isopropyl motif bearing hydroxyethylene dipeptide isostere analogues of aliskiren are in vitro potent inhibitors of the human aspartyl protease renin Discovery of highly potent renin inhibitors potentially interacting with the S3′ subsite of renin Design and synthesis of a potent and specific renin inhibitor with a prolonged duration of action in vivo Design and optimization of renin inhibitors: Orally bioavailable alkyl amines Structure-based design of a new series of N-(piperidin-3-yl)pyrimidine-5-carboxamides as renin inhibitors Novel renin inhibitors containing analogs of statine retro-inverted at the C-termini. Specificity at the P2 histidine site Renin inhibitors. Syntheses of subnanomolar, competitive, transition-state analog inhibitors containing a novel analog of statine Pepstatin analogs as novel renin inhibitors Optimization of orally bioavailable alkyl amine renin inhibitors Orally potent human renin inhibitors derived from angiotensinogen transition state: design, synthesis, and mode of interaction