Synthesis of unsymmetrically substituted 1,4-bis[(aminoalkyl)amino]anthracene-9,10-diones as potential antileukemic agents

Journal of Medicinal Chemistry
1989.0

Abstract

The synthesis of unsymmetrically substituted 1,4-bis[(aminoalkyl)amino]anthracene-9,10-diones bearing one "mitoxantrone side arm" and another (aminoalkyl)amino moiety has been described. These unsymmetrical anthracene-9,10-diones exhibit cytotoxic activity against L1210 leukemia cells and antitumor activity against P388 leukemia in mice.

Knowledge Graph

Similar Paper

Synthesis of unsymmetrically substituted 1,4-bis[(aminoalkyl)amino]anthracene-9,10-diones as potential antileukemic agents
Journal of Medicinal Chemistry 1989.0
6,9-Bis[(aminoalkyl)amino]benzo[g]isoquinoline-5,10-diones. A Novel Class of Chromophore-Modified Antitumor Anthracene-9,10-diones: Synthesis and Antitumor Evaluations
Journal of Medicinal Chemistry 1994.0
Synthesis and antineoplastic evaluations of 1,4-bis(aminoalkanamido)-9,10-anthracenediones
Journal of Medicinal Chemistry 1988.0
Synthesis and antitumor evaluations of symmetrically and unsymmetrically substituted 1,4-bis[(aminoalkyl)amino]anthracene-9,10-diones and 1,4-bis[(aminoalkyl)amino]-5,8-dihydroxyanthracene-9,10-diones
Journal of Medicinal Chemistry 1991.0
Antitumor agents. 1. 1,4-Bis[(aminoalkyl)amino]-9,10-anthracenediones
Journal of Medicinal Chemistry 1979.0
Structural modification study of mitoxantrone (DHAQ). Chloro-substituted mono- and bis[(aminoalkyl)amino]anthraquinones
Journal of Medicinal Chemistry 1987.0
Antineoplastic agents. Structure-activity relationship study of bis(substituted aminoalkylamino)anthraquinones
Journal of Medicinal Chemistry 1978.0
Chromophore-Modified Antitumor Anthracenediones: Synthesis, DNA Binding, and Cytotoxic Activity of 1,4-Bis[(aminoalkyl)amino]benzo[g]phthalazine-5,10-diones
Journal of Medicinal Chemistry 1995.0
Benzothiopyranoindazoles, a new class of chromophore modified anthracenedione anticancer agents. Synthesis and activity against murine leukemias
Journal of Medicinal Chemistry 1988.0
Anthrapyrazole anticancer agents. Synthesis and structure-activity relationships against murine leukemias
Journal of Medicinal Chemistry 1987.0